i'm not a LO8 specialist, but i'll take a quick stab at this:
- i think it's fine to see a flop with the non-nut low draws, but you'll really want to have good reads on when your hand is NG. if you play A4xx, you'll want the ace to be suited and/or the side cards to be coordinated somehow. furthermore, you REALLY want to see a 2 or 3 flop.
- while a lot of people will disagree with this, in super loose games, you can play just about any omaha hi hand profitably. the conditions are that you need to see a flop relatively cheaply (e.g., 2 bets), you can let go of your hand if you whiff, and lots of people will see a flop and pay off on later streets. one advantage of playing "loose" like this is that you get to catch a lot of janky flops that no one will think that you hit.
- if people are calling raises post-flop, don't be afraid to jam draws when you have an equity edge.
- figure out who's tight and who's not and adjust your play accordingly.
- don't get fooled by people who are loose pf but tight post-flop. you can lose a lot of money to these people.
that's all i can think of now.