I spent the holiday weekend in Vegas and played about 30.5 hours playing mostly 1/2 NLHE. Ended the trip up $978 and up close to 400 after expenses (had a free airline ticket ) Played at the Mirage, Rio, Sahara, Aladdin and Harrahs.
The Rio set up for the WSOP is pretty cool. I was there the morning after Dolyle won his 10th bracelet. At 7:30 AM there were oonly about 5 or 6 tables going, by 2:00 it was nut to butts in the whole room.
I found the smaller rooms to be much more profitbale. I had to grind it out at the Mirage and Rio but the players at Aladdin and Harrahs basically handed me their money. Good times.
So, my advice is to play the bigger/nicer rooms for the experience of it all but play the hole in the wall rooms for profit.