The Pre-flop, Flop, and River Caps are no brainers. With a Maniac and a bunch of tilters, this is mandatory.
The turn though, we can pretty much ignore what UTG has, since it is usually +EV to bet the value of your hand without considering his. CO though, we need to watch him closely, The pot is big enough that there is no reason for him to stay passive. If he does raise though, we still have odds to call for our 4 outer....