I'm not really as great as the experienced players around here, just playing for a month or 2, so maybe I'm totally wrong here but I'll try..
It looks like KK for LadyOne and Maybe 44 or K4 for LadyTwo, maybe they have TPTK or even A straight draw with A5 as I don't know what kind of players they are.. But seriously if I were in your position right there, I would really fold here, because you have the lowest trips, with 44 maybe I called but with 22 it's more likely that they have a higher set.
Again maybe I'm totally off here, but anyway I tried to help